Alabama Rot, or CRGV (Cutaneous and Renal Glomerular Vasculopathy) is a
disease first described back in the 1980s in a number of Greyhounds in Alabama,
USA – hence the name. However since 2012, more than a hundred dogs across the
UK, have been identified as having the same, or a very similar, disease.
Symptoms
The
majority of dogs will initially show skin lesions, typically appearing as
ulcers or erosions on the lower limbs, tummy or around the mouth and nose. A
few days later, the kidneys go into rapid failure, and the pet will suddenly
show signs of severe illness, with 80% of dogs going on to die, despite their vets’
best efforts at treatment.
Tests
The kidney failure that occurs is thought to be a result of inflammation
and damage to the lining of the blood vessels that supply the organs. This
leads to widespread formation of tiny blood clots, and consumption of
platelets, leading to a low platelet count in most cases. Anaemia (low red
blood cell count) and changes in white blood cell and bilirubin levels may also
be identified on routine blood tests. However there is no specific blood test
that can be performed to detect CRGV, as the cause is not yet known. Therefore
sadly, the only way to diagnose it is post-mortem, when samples of kidney tissue
may be examined under the microscope, to identify the characteristic changes
that occur.
Treatment
If you take your dog to the vet with a skin lesion, they will be
able to assess it and decide on the best course of action. Treatments may
include antibiotics, anti-inflammatories, ointments and protective dressings,
depending on the nature of the lesion. However they will not be able to
tell if the lesion is due to CRGV. Should your dog go on to become unwell, they
will advise performing further tests to investigate, along with more intensive
treatment. Sometimes referral to a Specialist veterinary centre (where vets
with additional qualifications, experience and facilities see unusual cases or
very poorly pets), may be advised, in order to give your dog the best chance of
recovery possible.
Predisposing factors
A wide
range of breeds have been identified with CRGV in the UK, suggesting the
disease does not solely affect greyhounds here. In fact, there does not appear
to be a breed, body weight, sex or age predilection. Neither does there seem to
be a particular geographical distribution for the disease, as whilst initially most
cases were seen in and around the New Forest, many other cases have now been
identified across the whole of the UK. However there does appear to be a
seasonality to the disease, with most cases being identified between November
and May ie. the Winter months. Muddy walks – often unavoidable at this time of
year – may be a significant risk factor.
What can dog owners do?
With the cause of CRGV currently unknown, the best advice is to be
vigilant and seek veterinary advice if you have any concerns about your pet. In
particular, be on the look-out for any skin sores not known to have been caused
by injury, especially below the elbow or knee. Reduced appetite, vomiting and
increased tiredness in your pet should never be ignored, and with these
symptoms we would advise that the sooner you take your pet to the vet, the
better. This is because these symptoms are non-specfic, which means they may be
indicators of a whole array of diseases and disorders, ranging from mild
disease due to an upset tummy, right through to very severe disease including
kidney failure and CRGV.
With a link to mud (or something in it) being hypothesised, it would also
seem prudent to make sure to wash-off your pet thoroughly, especially after
muddy walks.
Future research
Investigations into CRGV are ongoing, with the referral centre Anderson
Moores, in Hampshire, leading the way. They organised a conference earlier this
year, at which leading experts in kidney disease, from both the veterinary and
human medical fields, met to discuss the disease and how they could collaborate
going forwards. The Alabama Rot Research Fund is a National charity that has
been set up with the aim of raising awareness and funds for Alabama Rot
research www.arrf.co.uk.
Elly Pittaway is Veterinary Surgeon and owner of Broad Lane Vets, an
award-winning, family-run practice established in 1969, and with sites at Balsall
Common, Broad Lane and Radford Road in Coventry. For more information about the
practice please visit www.broadlanevets.co.uk. You can
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